Darolutamide
The The titration of rosuvastatin from 10 to 20 mg in Japanese patients with heterozygous familial hypercholesterolemia brought additional, significant improvements in all lipid parameters
According to the FDA Public Health Advisory, in a phase IV pharmacokinetic study “involving a diverse population of Asians residing in the United States
0) ng/mL for Asians and Whites, respectively
The Food and Drug Administration recommends rosuvastatin dosage reductions in Asian patients because pharmacokinetic studies have demonstrated an
The recommended dosage range is 5 mg to 10 mg orally once daily in patients aged 8 years to less than 10 years and 5 mg to 20 mg orally once daily in
drug levels) [10 yo and older] Dose: 5-20 mg PO qd; Info: may adjust dose q4wk;
Asian people may be particularly sensitive to rosuvastatin and require lower dosages
421AA genotype Max: 20 mg once daily
rosuvastatin + niacin (vitamin B3) if niacin dose >1000 mg/day, use alternative or monitor CK, myopathy sx, especially during initiation/titration: combo may incr
3)]
Consider specialist supervision when prescribing rosuvastatin above 20 mg daily For patients taking regorafenib, teriflunomide, enasidenib, or capmatinib, the dose of CRESTOR should not exceed 10 mg once daily
Discontinue rosuvastatin if markedly elevated CK levels occur or myopathy is
Limitations of use ( 1
2000 to Sep
For people with kidney disease initiate with 5 mg/day and do not exceed 10 mg/day
Common side effects are headache, muscle ache, abdominal pain, weakness, and nausea
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do
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People of Asian descent may absorb rosuvastatin at a higher rate than other people
Overall, 81% achieved LDL target with
The Food and Drug Administration recommends rosuvastatin dosage reductions in Asian patients because pharmacokinetic studies have demonstrated an approximate 2-fold increase in median exposure to rosuvastatin in Asian subjects compared with Caucasian controls
8)]
The 40 mg dose is contraindicated in these patients